Everything about Piroxicam totally explained
,
| PubChem = 5280452
| DrugBank = APRD01187
| C = 15 | H = 13 | N = 3 | O = 4 | S = 1
| molecular_weight = 331.348 g/mol
| bioavailability =
| protein_bound =
| metabolism = 4 to 10%
renal
| elimination_half-life = 30 to 86 hours
| pregnancy_category = C, D if used in the third trimester or near delivery
| legal_status = POM
| routes_of_administration = PO
| excretion = 4 to 10% renal
}}
Piroxicam is a
non-steroidal anti-inflammatory drug used to relieve the symptoms of
rheumatoid and
osteoarthritis, primary
dysmenorrhoea, postoperative pain; and act as an
analgesic, especially where there's an
inflammatory component. It is manufacturerd by
Pfizer under the tradename
Feldene, and is available in the and .
It is also used in
veterinary medicine to treat certain
neoplasias expressing
cyclooxygenase (COX) receptors, such as
bladder,
colon, and
prostate cancers.
Other brand names for Piroxicam include "Brexidol", "Brexin", "Erazon", "Felden", "Feldoral", "Hotemin", "Pirox von ct", "Proponol", "Reumador", "Tracam", "Veral", and "Vurdon".
Mechanism of action
Piroxicam is an
NSAID and, as such, is a non-selective
COX inhibitor possessing both analgesic and antipyretic properties. It undergoes entero-hepatic circulation.
Adverse effects
Piroxicam use can result in
gastrointestinal toxicity,
tinnitus,
dizziness,
headache,
rash, and
pruritus. The most severe adverse reactions are
peptic ulceration and gastrointestinal bleeding. Approximately 30% of all patients receiving daily doses of 20 mg of piroxicam experience side effects.
Piroxicam may cause skin to become more sensitive to sunlight. Avoidance of sunlight and use of sunscreen is recommended.
Footnotes
Further Information
Get more info on 'Piroxicam'.
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